Īt first, it was considered only a respiratory disease, afterward, it was found that Covid-19 can cause a large range of complications and systemic involvement (thromboembolic, gastrointestinal, cardiovascular, immune, renal, and neurological) that can lead to multiple organ dysfunction. Eighty percent of them were hospitalized and 7.4% died from complications of infection.
The 2019 coronavirus disease (Covid-19) has affected thousands of people worldwide. The vaccine could surface a silent herpes virus infection, which would induce the erythema multiforme instead. The causal role of the vaccine for the erythema multiforme has not been proven yet nevertheless, it is not uncommon for medications to trigger this disease. The present reports represent some of the few cases of erythema multiforme occurring as a side effect of the BNT162b2 COVID-19 vaccination. All the cases were treated with prednisone via oral administration and topical 0.05% clobetasol ointment. Three of the cases presented the erythema after the first vaccination dosage administration, only one case reported lesions after the second vaccination dosage administration. Two of the reported cases (number 1 and 2) presented with both oral and cutaneous lesions, while cases 3 and 4 showed only oral manifestations. All the patients denied previous erythema-like and herpetic manifestations history. We report four cases of oral erythema multiforme flare arising after BNT162b2 vaccination administration. Cutaneous reactions like urticaria, local injection site pain, morbilliform rash have been documented after vaccination. After vaccination, local and systemic adverse effects can occur. Four vaccinations have been outwardly approved by European Medicine Agency (EMA) in Europe: BNT162b2 (Comirnaty-BioNTech/Pfizer), mRNA-1273 (Spikevax-Moderna), ChAdOx1 (VaxzevriaAstrazeneca), and Ad26.COV2-S (Janssen-Johnson&Johnson). To date, vaccines appear to be the only method to prevent and reduce mortality. The 2019 Coronavirus disease (Covid-19) has affected thousands of people worldwide.
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